PHYTOMODULATORY EFFECTS OF MURRAYA KOENIGII IN DMBA/TPA INDUCED ANGIOGENESIS, HEPATOTOXICITY AND RENAL TOXICITY DURING SKIN CARCINOGENESIS IN MICE

The present study was aimed to evaluate the protective effects of Hydroethanolic Murraya koenigii leaves extract (HEMKLE) against DMBA/TPA-induced angiogenesis, hepatotoxicity and renal toxicity during skin carcinogenesis in mice. For study, male LACA mice were divided into four groups: Group I (C), II (DMBA/TPA), III (HEMKLE), IV (HEMKLE+DMBA/TPA). 7, 12-dimethylbenz(a) anthracene (DMBA), 12-O-tetradecanoyl phorbol-13-acetate (TPA) applied on depilated raise tumors IV. chemopreventive response HEMKLE evident by histoarchitectural morphometric analysis skin/tumors In addition, administration also decreased mRNA protein expression HIF-1α, HMOX-1, VEGF, bFGF, ANGPT-2 (HEMKLE+DMBA/TPA) when compared (DMBA/TPA) that suggest its anti-angiogenic effect. Moreover, protected liver kidney tissues from damages incurred as through histological analysis, assessment ROS LPO levels, function markers (viz., SGOT, SGPT, D-bilirubin, T-bilirubin, ALP, urea, creatinine BUN) activities antioxidant enzymes (HEMKLE +DMBA/TPA) (DMBA/TPA). outcome showed markedly alleviated angiogenesis carcinogenesis. However, further extensive studies are needed explore efficacy metastasis before going human trials.